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We use this expression to say that someone is obsessed with something or always thinks about something. It's often negative.
Written: No
Spoken: Yes
Formal: No
Informal: Yes
Example 1
I get so bored talking to Nigel. All he's interested in is football.
I know. He's got football on the brain.
Example 2
Are you coming to the party on Friday? Donna will be there. Donna's great.
Will you shut up about Donna! You've got her on the brain!
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